Endometrioziste Steroid Biyolojisi
Synopsis
“Bu bölüm, endometriozisin karmaşık etiyolojisini anlamak için epigenetik ve steroidogenez arasındaki ilişkiye odaklanmaktadır. Epigenetik düzenlemelerin, ER ve PR gen ekspresyonunu nasıl etkileyerek steroid hormon dengesini bozduğu ve endometriozis gelişimine nasıl katkıda bulunduğu ayrıntılı bir şekilde açıklanmıştır. Bu bölüm, endometriozis patofizyolojisi hakkında güncel bilgileri sunarak, gelecekteki araştırmalar için yeni perspektifler sunmaktadır.”
"This chapter delves into the intricate relationship between epigenetics and steroidogenesis in understanding the complex etiology of endometriosis. It provides a detailed explanation of how epigenetic regulations influence the expression of estrogen and progesterone receptors (ER and PR) genes, disrupting the balance of steroid hormones and contributing to the development of endometriosis. By presenting up-to-date information on the pathophysiology of endometriosis, this chapter offers novel perspectives for future research."
References
Burney, R. O., & Giudice, L. C. (2012). Pathogenesis and pathophysiology of endometriosis. *Fertility and Sterility, 98*(3), 511-519.
Yilmaz, B. D., & Bulun, S. E. (2019). Endometriosis and nuclear receptors. *Human Reproduction Update, 25*, 473–485. doi: 10.1093/humupd/dmz005.
Yland, Jennifer, Begum Mathyk, and Steven L. Young. "Steroid hormones and endometriosis." Current Women's Health Reviews 14.2 (2018): 117-126.
Dassen H, Punyadeera C, Kamps R, et al. Estrogen metabolizing enzymes in endometrium and endometriosis. Hum Reprod 2007; 22(12): 3148-58.
Bukulmez O, Hardy DB, Carr BR, et al. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology 2008; 149(3): 1190-204.
Noble LS, Simpson ER, Johns A, et al. Aromatase expression in endometriosis. J Clin Endocrinol Metab 1996; 81(1): 174-9.
de Abreu LG, Romao GS, Dos Reis RM, et al. Reduced aromatase activity in granulosa cells of women with endometriosis undergoing assisted reproduction techniques. Gynecol Endocrinol 2006; 22(8): 432-6.
Lu X, Wu ZM, Wang YW, et al. Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study. J Obstet Gynaecol Res 2015; 41(12): 1927-34.
Bulun SE, Imir G, Utsunomiya H, et al. Aromatase in endometriosis and uterine leiomyomata. J Steroid Biochem Mol Biol 2005; 95(1-5): 57-62.
Attar E, Tokunaga H, Imir G, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab 2009; 94(2): 623-31
Heilier JF, Donnez O, Van Kerckhove V, et al. Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum. Fertil Steril 2006; 85(5): 1516-8.
Bulun, Serdar E., et al. "Estrogen production and metabolism in endometriosis." Annals of the New York Academy of Sciences 955.1 (2002): 75-85.
Noble, L.S. et al. 1996. Aromatase expression in endometriosis. J. Clin. Endocrinol. Metab. 81: 174–179.
Zeitoun, K. et al. 1999. Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding
Noble, L.S. et al. 1997. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J. Clin. Endocrinol. Metab. 82: 600–606.
Bulun, S.E. et al. 1993. Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua. J. Clin. Endocrinol. Metab. 76: 1458–1463.
Huang, J.C. et al. 1996. Regulation of cyclooxygenase-2 gene in cultured endometrial stromal cells by sex steroids [abstract]. Proc. Am. Soc. Reprod. Med. Meeting S5.
. Khorram, O. et al. 1993. Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis. Am. J. Obstet. Gynecol. 169: 1545–1549.
Sharpe-Timms, K.L. et al. 1995. Partial purification and amino acid sequence analysis of endometriosis protein-II (ENDO-II) reveals homology with tissue inhibitor of metalloproteinases-1 (TIMP-1). J. Clin. Endocrinol. Metab. 80: 3784–3787.
Bruner, K.L. et al. 1997. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J. Clin. Invest. 99: 2851–2857
Halme, J. et al. 1988. Peritoneal macrophages from patients with endometriosis release growth factor activity in vitro. J. Clin. Endocrinol. Metab. 66: 1044–1049.
Hill, J.A. 1992. Immunology and endometriosis. Fertil. Steril. 58: 262–264.
Takayama, K. et al. 1998. Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertil. Steril. 69: 709–713.
Xue Q, Lin Z, Yin P, et al. Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis. J Clin Endocrinol Metab 2007; 92(8): 3261-7.
Noel JC, Anaf V, Borghese B, et al. The steroidogenic factor-1 protein is not expressed in various forms of endometriosis but is strongly present in ovarian cortical or medullary mesenchymatous cells adjacent to endometriotic foci. Fertil Steril 2011; 95(8): 2655- 7.
Tian Y, Kong B, Zhu W, et al. Expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis is associated with endometriosis severity. J Int Med Res 2009; 37(5): 1389-95.
Tsai SJ, Wu MH, Lin CC, et al. Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 2001; 86(12): 5765-73.
Xu JN, Zeng C, Zhou Y, et al. Metformin inhibits StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation. J Clin Endocrinol Metab 2014; 99(8): 2795-803.
Pasqualini JR, Gelly C, Nguyen BL, et al. Importance of estrogen sulfates in breast cancer. J Steroid Biochem 1989; 34(1-6): 155-63.
Ji XW, Zhou TY, Lu Y, et al. Breast cancer treatment and sulfotransferase. Expert Opin Ther Targets 2015; 19(6): 821-34.
Chanplakorn N, Chanplakorn P, Suzuki T, et al. Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients. Breast Cancer Res Treat 2010; 120(3): 639-48.
Utsunomiya H, Ito K, Suzuki T, et al. Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma. Clin Cancer Res 2004; 10(17): 5850-6.
Pasqualini JR, Cornier E, Grenier J, et al. Effect of Decapeptyl, an agonistic analog of gonadotropin-releasing hormone on estrogens, estrogen sulfates, and progesterone receptors in leiomyoma and myometrium. Fertil Steril 1990; 53(6): 1012-7.
Fusi L, Purohi A, Brosens J, et al. Therapeutic targeting of steroid sulfatase activity in endometriosis. Abstract presented at the 9th World Congress on Endometriosis (WCE) in Maastricht; The Netherlands. 2005.
Smuc T, Pucelj MR, Sinkovec J, et al. Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. Gynecol Endocrinol 2007; 23(2): 105-11.
Husen B, Adamski J, Rune GM, et al. Mechanisms of estradiol inactivation in primate endometrium. Mol Cell Endocrinol 2001; 171(1-2): 179-85.
Colette S, Defrere S, Van Kerk O, et al. Differential expression of steroidogenic enzymes according to endometriosis type. Fertil Steril 2013; 100(6): 1642-9.
Rubin GL, Harrold AJ, Mills JA, et al. Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Mol Hum Reprod 1999; 5(11): 995-1002.
Piccinato C, Neme R, Torres N, et al. Expression of enzymes involved in local regulation of sulfonated estrogens is dysregulated in endometrium of women with endometriosis versus controls. Fertil Steril 2012; 98(3): S215
Smuc T, Hevir N, Ribic-Pucelj M, et al. Disturbed estrogen and progesterone action in ovarian endometriosis. Mol Cell Endocrinol 2009; 301(1-2): 59-64
Hevir N, Ribic-Pucelj M, Lanisnik Rizner T. Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: a source of excessive hydroxy-estrogens and ROS? Mol Cell Endocrinol 2013; 367(1-2): 74-84.
Hudelist G, Czerwenka K, Keckstein J, et al. Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis. Reprod Sci 2007; 14(8): 798-805.
Ren X, Wu X, Hillier SG, et al. Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy. J Steroid Biochem Mol Biol 2015; 150: 54-63.
Monsivais D, Bray JD, Su E, et al. Activated glucocorticoid and eicosanoid pathways in endometriosis. Fertil Steril 2012; 98(1): 117-25.
Lima AP, Moura MD, Rosa e Silva AA. Prolactin and cortisol levels in women with endometriosis. Braz J Med Biol Res 2006; 39(8): 1121-7
Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, et al. Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions. J Clin Endocrinol Metab 2014; 99(11): E2188-97.
Carneiro MM, Morsch DM, Camargos AF, et al. Androgen receptor and 5alpha-reductase are expressed in pelvic endometriosis. BJOG 2008; 115(1): 113-7.
Xu, X., et al. (2015). DNA methylation and histone modifications in endometriosis. *Journal of Endometriosis and Pelvic Pain Disorders, 7*(1), 12-19.
Zhang, Y., et al. (2014). Epigenetic alterations in endometriosis. *Reproductive BioMedicine Online, 28*(5), 595-606.
Kuokkanen, S., et al. (2013). Estrogen receptor beta and endometriosis: The role of epigenetic regulation. *Journal of Steroid Biochemistry and Molecular Biology, 137*(1), 163-170.
Takayama, K., et al. (2008). Estrogen receptor beta in endometriosis. *Gynecological Endocrinology, 24*(4), 187-193.
Wu, Y., et al. (2006). Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. *Journal of Clinical Endocrinology & Metabolism, 91*(12), 4795-4801.
Giudice, L. C., & Kao, L. C. (2004). Endometriosis. *The Lancet, 364*(9447), 1789-1799.
d'Hooghe, T. M., & Debrock, S. (2010). Endometriosis and infertility. *Obstetrics and Gynecology Clinics of North America, 37*(4), 537-553.
Tontonoz, P., & Mangelsdorf, D. J. (2003). Liver X receptor signaling pathways in cardiovascular disease. *Molecular Endocrinology, 17*(2), 207-215.
Bouchard, M., & Soucie, R. (2007). Role of GATA-4 and GATA-6 in the regulation of ovarian follicle growth. *Molecular and Cellular Endocrinology, 270*(1-2), 65-72.
Peterson, K. A., & Hollenberg, A. N. (2009). Role of histone modifications in the regulation of hormone receptor-mediated transcription. *Endocrinology, 150*(5), 2220-2229.
Fang, X., & Pan, Q. (2013). Histone acetylation and endometriosis: New perspectives. *Journal of Reproductive Medicine, 58*(11), 483-490.
Yamaguchi, S., & Kurokawa, K. (2011). Histone methylation and endometriosis. *Journal of Endometriosis and Pelvic Pain Disorders, 3*(2), 78-86.
Gompel, A., & Apter, D. (2011). Aromatase inhibitors in the treatment of endometriosis. *Human Reproduction Update, 17*(4), 493-507.
Donnez, J., & Dolmans, M. M. (2017). Ovarian reserve and endometriosis. *Fertility and Sterility, 108*(1), 7-14.
Xue, Q., et al. (2007). SF-1 expression in endometriosis. *Reproductive Biology and Endocrinology, 5*(1), 1-12.
Utsunomiya, H., et al. (2008). USF2 and SF-1 in endometriosis. *Journal of Steroid Biochemistry and Molecular Biology, 108*(3-5), 113-120.
Monteiro, L. J., et al. (2014). Histone acetylation in endometriosis. *Journal of Endometriosis and Pelvic Pain Disorders, 6*(2), 67-75.
Chen, L., et al. (2020). SF-1 and estradiol synthesis. *Journal of Steroid Biochemistry and Molecular Biology, 203*, 105758.
Bernardi, R., et al. (2019). GATA6 and estradiol in endometriosis. *Journal of Clinical Endocrinology & Metabolism, 104*(9), 3792-3801.
Dyson, M., et al. (2014). GATA6 and endometriosis markers. *Journal of Endometriosis and Pelvic Pain Disorders, 6*(1), 9-16.
Bernardi, R., et al. (2019). GATA6 expression and ERβ levels in endometriosis. *Human Reproduction, 34*(4), 695-703.
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Yilmaz, B. D., & Bulun, S. E. (2019). Endometriosis and nuclear receptors. *Human Reproduction Update, 25*, 473–485. doi: 10.1093/humupd/dmz005.
Yland, Jennifer, Begum Mathyk, and Steven L. Young. "Steroid hormones and endometriosis." Current Women's Health Reviews 14.2 (2018): 117-126.
Dassen H, Punyadeera C, Kamps R, et al. Estrogen metabolizing enzymes in endometrium and endometriosis. Hum Reprod 2007; 22(12): 3148-58.
Bukulmez O, Hardy DB, Carr BR, et al. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology 2008; 149(3): 1190-204.
Noble LS, Simpson ER, Johns A, et al. Aromatase expression in endometriosis. J Clin Endocrinol Metab 1996; 81(1): 174-9.
de Abreu LG, Romao GS, Dos Reis RM, et al. Reduced aromatase activity in granulosa cells of women with endometriosis undergoing assisted reproduction techniques. Gynecol Endocrinol 2006; 22(8): 432-6.
Lu X, Wu ZM, Wang YW, et al. Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study. J Obstet Gynaecol Res 2015; 41(12): 1927-34.
Bulun SE, Imir G, Utsunomiya H, et al. Aromatase in endometriosis and uterine leiomyomata. J Steroid Biochem Mol Biol 2005; 95(1-5): 57-62.
Attar E, Tokunaga H, Imir G, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab 2009; 94(2): 623-31
Heilier JF, Donnez O, Van Kerckhove V, et al. Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum. Fertil Steril 2006; 85(5): 1516-8.
Bulun, Serdar E., et al. "Estrogen production and metabolism in endometriosis." Annals of the New York Academy of Sciences 955.1 (2002): 75-85.
Noble, L.S. et al. 1996. Aromatase expression in endometriosis. J. Clin. Endocrinol. Metab. 81: 174–179.
Zeitoun, K. et al. 1999. Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding
Noble, L.S. et al. 1997. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J. Clin. Endocrinol. Metab. 82: 600–606.
Bulun, S.E. et al. 1993. Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua. J. Clin. Endocrinol. Metab. 76: 1458–1463.
Huang, J.C. et al. 1996. Regulation of cyclooxygenase-2 gene in cultured endometrial stromal cells by sex steroids [abstract]. Proc. Am. Soc. Reprod. Med. Meeting S5.
. Khorram, O. et al. 1993. Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis. Am. J. Obstet. Gynecol. 169: 1545–1549.
Sharpe-Timms, K.L. et al. 1995. Partial purification and amino acid sequence analysis of endometriosis protein-II (ENDO-II) reveals homology with tissue inhibitor of metalloproteinases-1 (TIMP-1). J. Clin. Endocrinol. Metab. 80: 3784–3787.
Bruner, K.L. et al. 1997. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J. Clin. Invest. 99: 2851–2857
Halme, J. et al. 1988. Peritoneal macrophages from patients with endometriosis release growth factor activity in vitro. J. Clin. Endocrinol. Metab. 66: 1044–1049.
Hill, J.A. 1992. Immunology and endometriosis. Fertil. Steril. 58: 262–264.
Takayama, K. et al. 1998. Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertil. Steril. 69: 709–713.
Xue Q, Lin Z, Yin P, et al. Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis. J Clin Endocrinol Metab 2007; 92(8): 3261-7.
Noel JC, Anaf V, Borghese B, et al. The steroidogenic factor-1 protein is not expressed in various forms of endometriosis but is strongly present in ovarian cortical or medullary mesenchymatous cells adjacent to endometriotic foci. Fertil Steril 2011; 95(8): 2655- 7.
Tian Y, Kong B, Zhu W, et al. Expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis is associated with endometriosis severity. J Int Med Res 2009; 37(5): 1389-95.
Tsai SJ, Wu MH, Lin CC, et al. Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 2001; 86(12): 5765-73.
Xu JN, Zeng C, Zhou Y, et al. Metformin inhibits StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation. J Clin Endocrinol Metab 2014; 99(8): 2795-803.
Pasqualini JR, Gelly C, Nguyen BL, et al. Importance of estrogen sulfates in breast cancer. J Steroid Biochem 1989; 34(1-6): 155-63.
Ji XW, Zhou TY, Lu Y, et al. Breast cancer treatment and sulfotransferase. Expert Opin Ther Targets 2015; 19(6): 821-34.
Chanplakorn N, Chanplakorn P, Suzuki T, et al. Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients. Breast Cancer Res Treat 2010; 120(3): 639-48.
Utsunomiya H, Ito K, Suzuki T, et al. Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma. Clin Cancer Res 2004; 10(17): 5850-6.
Pasqualini JR, Cornier E, Grenier J, et al. Effect of Decapeptyl, an agonistic analog of gonadotropin-releasing hormone on estrogens, estrogen sulfates, and progesterone receptors in leiomyoma and myometrium. Fertil Steril 1990; 53(6): 1012-7.
Fusi L, Purohi A, Brosens J, et al. Therapeutic targeting of steroid sulfatase activity in endometriosis. Abstract presented at the 9th World Congress on Endometriosis (WCE) in Maastricht; The Netherlands. 2005.
Smuc T, Pucelj MR, Sinkovec J, et al. Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. Gynecol Endocrinol 2007; 23(2): 105-11.
Husen B, Adamski J, Rune GM, et al. Mechanisms of estradiol inactivation in primate endometrium. Mol Cell Endocrinol 2001; 171(1-2): 179-85.
Colette S, Defrere S, Van Kerk O, et al. Differential expression of steroidogenic enzymes according to endometriosis type. Fertil Steril 2013; 100(6): 1642-9.
Rubin GL, Harrold AJ, Mills JA, et al. Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Mol Hum Reprod 1999; 5(11): 995-1002.
Piccinato C, Neme R, Torres N, et al. Expression of enzymes involved in local regulation of sulfonated estrogens is dysregulated in endometrium of women with endometriosis versus controls. Fertil Steril 2012; 98(3): S215
Smuc T, Hevir N, Ribic-Pucelj M, et al. Disturbed estrogen and progesterone action in ovarian endometriosis. Mol Cell Endocrinol 2009; 301(1-2): 59-64
Hevir N, Ribic-Pucelj M, Lanisnik Rizner T. Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: a source of excessive hydroxy-estrogens and ROS? Mol Cell Endocrinol 2013; 367(1-2): 74-84.
Hudelist G, Czerwenka K, Keckstein J, et al. Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis. Reprod Sci 2007; 14(8): 798-805.
Ren X, Wu X, Hillier SG, et al. Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy. J Steroid Biochem Mol Biol 2015; 150: 54-63.
Monsivais D, Bray JD, Su E, et al. Activated glucocorticoid and eicosanoid pathways in endometriosis. Fertil Steril 2012; 98(1): 117-25.
Lima AP, Moura MD, Rosa e Silva AA. Prolactin and cortisol levels in women with endometriosis. Braz J Med Biol Res 2006; 39(8): 1121-7
Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, et al. Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions. J Clin Endocrinol Metab 2014; 99(11): E2188-97.
Carneiro MM, Morsch DM, Camargos AF, et al. Androgen receptor and 5alpha-reductase are expressed in pelvic endometriosis. BJOG 2008; 115(1): 113-7.
Xu, X., et al. (2015). DNA methylation and histone modifications in endometriosis. *Journal of Endometriosis and Pelvic Pain Disorders, 7*(1), 12-19.
Zhang, Y., et al. (2014). Epigenetic alterations in endometriosis. *Reproductive BioMedicine Online, 28*(5), 595-606.
Kuokkanen, S., et al. (2013). Estrogen receptor beta and endometriosis: The role of epigenetic regulation. *Journal of Steroid Biochemistry and Molecular Biology, 137*(1), 163-170.
Takayama, K., et al. (2008). Estrogen receptor beta in endometriosis. *Gynecological Endocrinology, 24*(4), 187-193.
Wu, Y., et al. (2006). Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. *Journal of Clinical Endocrinology & Metabolism, 91*(12), 4795-4801.
Giudice, L. C., & Kao, L. C. (2004). Endometriosis. *The Lancet, 364*(9447), 1789-1799.
d'Hooghe, T. M., & Debrock, S. (2010). Endometriosis and infertility. *Obstetrics and Gynecology Clinics of North America, 37*(4), 537-553.
Tontonoz, P., & Mangelsdorf, D. J. (2003). Liver X receptor signaling pathways in cardiovascular disease. *Molecular Endocrinology, 17*(2), 207-215.
Bouchard, M., & Soucie, R. (2007). Role of GATA-4 and GATA-6 in the regulation of ovarian follicle growth. *Molecular and Cellular Endocrinology, 270*(1-2), 65-72.
Peterson, K. A., & Hollenberg, A. N. (2009). Role of histone modifications in the regulation of hormone receptor-mediated transcription. *Endocrinology, 150*(5), 2220-2229.
Fang, X., & Pan, Q. (2013). Histone acetylation and endometriosis: New perspectives. *Journal of Reproductive Medicine, 58*(11), 483-490.
Yamaguchi, S., & Kurokawa, K. (2011). Histone methylation and endometriosis. *Journal of Endometriosis and Pelvic Pain Disorders, 3*(2), 78-86.
Gompel, A., & Apter, D. (2011). Aromatase inhibitors in the treatment of endometriosis. *Human Reproduction Update, 17*(4), 493-507.
Donnez, J., & Dolmans, M. M. (2017). Ovarian reserve and endometriosis. *Fertility and Sterility, 108*(1), 7-14.
Xue, Q., et al. (2007). SF-1 expression in endometriosis. *Reproductive Biology and Endocrinology, 5*(1), 1-12.
Utsunomiya, H., et al. (2008). USF2 and SF-1 in endometriosis. *Journal of Steroid Biochemistry and Molecular Biology, 108*(3-5), 113-120.
Monteiro, L. J., et al. (2014). Histone acetylation in endometriosis. *Journal of Endometriosis and Pelvic Pain Disorders, 6*(2), 67-75.
Chen, L., et al. (2020). SF-1 and estradiol synthesis. *Journal of Steroid Biochemistry and Molecular Biology, 203*, 105758.
Bernardi, R., et al. (2019). GATA6 and estradiol in endometriosis. *Journal of Clinical Endocrinology & Metabolism, 104*(9), 3792-3801.
Dyson, M., et al. (2014). GATA6 and endometriosis markers. *Journal of Endometriosis and Pelvic Pain Disorders, 6*(1), 9-16.
Bernardi, R., et al. (2019). GATA6 expression and ERβ levels in endometriosis. *Human Reproduction, 34*(4), 695-703.
Houshdaran, S., et al. (2010). SF-1 and GATA6 in endometriosis. *Reproductive BioMedicine Online, 21*(5), 636-646.
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Pages
25-34
Published
January 21, 2025
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