Epilepsi Cerrahisine Hazırlıkta İlk Aşama ve Non-İnvazif Tetkiklerle Değerlendirme-Nükleer Tıp
Özet
Bu kitap bölümünde ilaca dirençli epilepsi hastalarının epilepsi cerrahisine hazırlanması aşamasında işlevsel Nükleer Tıp görüntüleme yöntemleri [Beyin perfüzyon SPECT (“Single Photon Emission Computed Tomography”) ve Floro Deoksi Glukoz (FDG) ile yapılan Pozitron Emiston Tomografisi (PET)] hakkında bilgi verilmeye çalışılmıştır. İşlevsel görüntüleme yöntemlerinin endikasyonları, tetkiklerin avantajları ve bu süreçte verdikleri bilgilerin çocuklardaki cerrahi planlamasındaki rolü anlatılmaya çalışılmıştır.
Referanslar
Thomsen, G. & Knudsen, G.M.: Procedure guideline for brain perfusion SPECT using 99mTc radiopharmaceuticals 3.0. J Nucl Med Technol. 2010; 38: 209.
Technetium Tc 99m Bicisate. (2006) in Drugs and Lactation Database (LactMed(R)) (Bethesda (MD).
Goffin, K. & van Laere, K.: Single-photon emission tomography. Handb Clin Neurol. 2016; 135: 241-250.
Grunwald, F., Menzel, C., Pavics, L. et al: Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD. J Nucl Med. 1994; 35: 1896-1901.
Newton, M.R., Berkovic, S.F., Austin, M.C., Rowe, C.C., McKay, W.J. & Bladin, P.F.: Postictal switch in blood flow distribution and temporal lobe seizures. J Neurol Neurosurg Psychiatry. 1992; 55: 891-894.
Vander Borght, T., Laloux, P., Maes, A. et al: Guidelines for brain radionuclide imaging. Perfusion single photon computed tomography (SPECT) using Tc-99m radiopharmaceuticals and brain metabolism positron emission tomography (PET) using F-18 fluorodeoxyglucose. The Belgian Society for Nuclear Medicine. Acta Neurol Belg. 2001; 101: 196-209.
Chassagnon, S., Namer, I.J., Armspach, J.P. et al: SPM analysis of ictal-interictal SPECT in mesial temporal lobe epilepsy: relationships between ictal semiology and perfusion changes. Epilepsy Res. 2009; 85: 252-260.
la Fougere, C., Rominger, A., Forster, S., Geisler, J. & Bartenstein, P.: PET and SPECT in epilepsy: a critical review. Epilepsy Behav. 2009; 15: 50-55.
Velasco, T.R., Wichert-Ana, L., Mathern, G.W. et al: Utility of ictal single photon emission computed tomography in mesial temporal lobe epilepsy with hippocampal atrophy: a randomized trial. Neurosurgery. 2011; 68: 431-436; discussion 436.
Wichert-Ana, L., Velasco, T.R., Terra-Bustamante, V.C. et al: Typical and atypical perfusion patterns in periictal SPECT of patients with unilateral temporal lobe epilepsy. Epilepsia. 2001; 42: 660-666.
von Oertzen, T.J., Mormann, F., Urbach, H. et al: Prospective use of subtraction ictal SPECT coregistered to MRI (SISCOM) in presurgical evaluation of epilepsy. Epilepsia. 2011; 52: 2239-2248.
O'Brien, T.J., So, E.L., Cascino, G.D. et al: Subtraction SPECT coregistered to MRI in focal malformations of cortical development: localization of the epileptogenic zone in epilepsy surgery candidates. Epilepsia. 2004; 45: 367-376.
Kudr, M., Krsek, P., Marusic, P. et al: SISCOM and FDG-PET in patients with non-lesional extratemporal epilepsy: correlation with intracranial EEG, histology, and seizure outcome. Epileptic Disord. 2013; 15: 3-13.
Wetjen, N.M., Cascino, G.D., Fessler, A.J. et al: Subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging in evaluating the need for repeated epilepsy surgery. J Neurosurg. 2006; 105: 71-76.
Haemels, M., Van Weehaeghe, D., Cleeren, E. et al: Predictive value of metabolic and perfusion changes outside the seizure onset zone for postoperative outcome in patients with refractory focal epilepsy. Acta Neurol Belg. 2022; 122: 325-335.
Ergun, E.L., Saygi, S., Yalnizoglu, D., Oguz, K.K. & Erbas, B.: SPECT-PET in Epilepsy and Clinical Approach in Evaluation. Semin Nucl Med. 2016; 46: 294-307.
Kim, Y.K., Lee, D.S., Lee, S.K., Chung, C.K., Chung, J.K. & Lee, M.C.: (18)F-FDG PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis. J Nucl Med. 2002; 43: 1167-1174.
Muzik, O., da Silva, E.A., Juhasz, C. et al: Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology. 2000; 54: 171-179.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology. 2000; 55: 825-835.
Juhasz, C., Nagy, F., Muzik, O., Watson, C., Shah, J. & Chugani, H.T.: [11C]Flumazenil PET in patients with epilepsy with dual pathology. Epilepsia. 1999; 40: 566-574.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology. 2003; 60: 960-968.
Ergün EL, E.B.: Çocukluk çağında epilepsi ve Nükleer tip. Katki Pediatri Dergisi. 2005; 27: 228-246.
Oguz KK, Ergün.EL. (2008) Epilepsi ve Fonksiyonel-Metabolik Görüntüleme. in Epilepsi. , Vol. 1 (ed. Bora İ, Y.S., Gürses C) (Nobel TİP Kitabevleri, Ankara.
Ergün EL (2011). Hareket bozuklukları, inme, epilepsi. in PET ve PET/BT Prensipler ve Uygulamalar.; (ed. Caner B, U.Ö., Bozkurt MF, ) ( Öncü Basimevi, Rotatip Kitabevi, Ankara.
Kumar, A. & Chugani, H.T.: The Role of Radionuclide Imaging in Epilepsy, Part 2: Epilepsy Syndromes. J Nucl Med Technol. 2017; 45: 22-29.
Pavone, P., Striano, P., Falsaperla, R., Pavone, L. & Ruggieri, M.: Infantile spasms syndrome, West syndrome and related phenotypes: what we know in 2013. Brain Dev. 2014; 36: 739-751.
Chugani, H.T., Shields, W.D., Shewmon, D.A., Olson, D.M., Phelps, M.E. & Peacock, W.J.: Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol. 1990; 27: 406-413.
Lee, J.S., Asano, E., Muzik, O. et al: Sturge-Weber syndrome: correlation between clinical course and FDG PET findings. Neurology. 2001; 57: 189-195.
De la Torre, A.J., Luat, A.F., Juhasz, C. et al: A Multidisciplinary Consensus for Clinical Care and Research Needs for Sturge-Weber Syndrome. Pediatr Neurol. 2018; 84: 11-20.
Alkonyi, B., Chugani, H.T. & Juhasz, C.: Transient focal cortical increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis. Epilepsia. 2011; 52: 1265-1272.
Kagawa, K., Chugani, D.C., Asano, E. et al: Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET). J Child Neurol. 2005; 20: 429-438.
Ferrendelli, J.A.: Lennox-Gastaut syndrome and positron emission tomography. Ann Neurol. 1987; 21: 3.
Ostendorf, A.P. & Ng, Y.T.: Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat. 2017; 13: 1131-1140.
Archer, J.S., Warren, A.E., Stagnitti, M.R., Masterton, R.A., Abbott, D.F. & Jackson, G.D.: Lennox-Gastaut syndrome and phenotype: secondary network epilepsies. Epilepsia. 2014; 55: 1245-1254.
Bordonne, M., Chawki, M.B., Doyen, M. et al: Brain (18)F-FDG PET for the diagnosis of autoimmune encephalitis: a systematic review and a meta-analysis. Eur J Nucl Med Mol Imaging. 2021; 48: 3847-3858.
Technetium Tc 99m Bicisate. (2006) in Drugs and Lactation Database (LactMed(R)) (Bethesda (MD).
Goffin, K. & van Laere, K.: Single-photon emission tomography. Handb Clin Neurol. 2016; 135: 241-250.
Grunwald, F., Menzel, C., Pavics, L. et al: Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD. J Nucl Med. 1994; 35: 1896-1901.
Newton, M.R., Berkovic, S.F., Austin, M.C., Rowe, C.C., McKay, W.J. & Bladin, P.F.: Postictal switch in blood flow distribution and temporal lobe seizures. J Neurol Neurosurg Psychiatry. 1992; 55: 891-894.
Vander Borght, T., Laloux, P., Maes, A. et al: Guidelines for brain radionuclide imaging. Perfusion single photon computed tomography (SPECT) using Tc-99m radiopharmaceuticals and brain metabolism positron emission tomography (PET) using F-18 fluorodeoxyglucose. The Belgian Society for Nuclear Medicine. Acta Neurol Belg. 2001; 101: 196-209.
Chassagnon, S., Namer, I.J., Armspach, J.P. et al: SPM analysis of ictal-interictal SPECT in mesial temporal lobe epilepsy: relationships between ictal semiology and perfusion changes. Epilepsy Res. 2009; 85: 252-260.
la Fougere, C., Rominger, A., Forster, S., Geisler, J. & Bartenstein, P.: PET and SPECT in epilepsy: a critical review. Epilepsy Behav. 2009; 15: 50-55.
Velasco, T.R., Wichert-Ana, L., Mathern, G.W. et al: Utility of ictal single photon emission computed tomography in mesial temporal lobe epilepsy with hippocampal atrophy: a randomized trial. Neurosurgery. 2011; 68: 431-436; discussion 436.
Wichert-Ana, L., Velasco, T.R., Terra-Bustamante, V.C. et al: Typical and atypical perfusion patterns in periictal SPECT of patients with unilateral temporal lobe epilepsy. Epilepsia. 2001; 42: 660-666.
von Oertzen, T.J., Mormann, F., Urbach, H. et al: Prospective use of subtraction ictal SPECT coregistered to MRI (SISCOM) in presurgical evaluation of epilepsy. Epilepsia. 2011; 52: 2239-2248.
O'Brien, T.J., So, E.L., Cascino, G.D. et al: Subtraction SPECT coregistered to MRI in focal malformations of cortical development: localization of the epileptogenic zone in epilepsy surgery candidates. Epilepsia. 2004; 45: 367-376.
Kudr, M., Krsek, P., Marusic, P. et al: SISCOM and FDG-PET in patients with non-lesional extratemporal epilepsy: correlation with intracranial EEG, histology, and seizure outcome. Epileptic Disord. 2013; 15: 3-13.
Wetjen, N.M., Cascino, G.D., Fessler, A.J. et al: Subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging in evaluating the need for repeated epilepsy surgery. J Neurosurg. 2006; 105: 71-76.
Haemels, M., Van Weehaeghe, D., Cleeren, E. et al: Predictive value of metabolic and perfusion changes outside the seizure onset zone for postoperative outcome in patients with refractory focal epilepsy. Acta Neurol Belg. 2022; 122: 325-335.
Ergun, E.L., Saygi, S., Yalnizoglu, D., Oguz, K.K. & Erbas, B.: SPECT-PET in Epilepsy and Clinical Approach in Evaluation. Semin Nucl Med. 2016; 46: 294-307.
Kim, Y.K., Lee, D.S., Lee, S.K., Chung, C.K., Chung, J.K. & Lee, M.C.: (18)F-FDG PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis. J Nucl Med. 2002; 43: 1167-1174.
Muzik, O., da Silva, E.A., Juhasz, C. et al: Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology. 2000; 54: 171-179.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology. 2000; 55: 825-835.
Juhasz, C., Nagy, F., Muzik, O., Watson, C., Shah, J. & Chugani, H.T.: [11C]Flumazenil PET in patients with epilepsy with dual pathology. Epilepsia. 1999; 40: 566-574.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology. 2003; 60: 960-968.
Ergün EL, E.B.: Çocukluk çağında epilepsi ve Nükleer tip. Katki Pediatri Dergisi. 2005; 27: 228-246.
Oguz KK, Ergün.EL. (2008) Epilepsi ve Fonksiyonel-Metabolik Görüntüleme. in Epilepsi. , Vol. 1 (ed. Bora İ, Y.S., Gürses C) (Nobel TİP Kitabevleri, Ankara.
Ergün EL (2011). Hareket bozuklukları, inme, epilepsi. in PET ve PET/BT Prensipler ve Uygulamalar.; (ed. Caner B, U.Ö., Bozkurt MF, ) ( Öncü Basimevi, Rotatip Kitabevi, Ankara.
Kumar, A. & Chugani, H.T.: The Role of Radionuclide Imaging in Epilepsy, Part 2: Epilepsy Syndromes. J Nucl Med Technol. 2017; 45: 22-29.
Pavone, P., Striano, P., Falsaperla, R., Pavone, L. & Ruggieri, M.: Infantile spasms syndrome, West syndrome and related phenotypes: what we know in 2013. Brain Dev. 2014; 36: 739-751.
Chugani, H.T., Shields, W.D., Shewmon, D.A., Olson, D.M., Phelps, M.E. & Peacock, W.J.: Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol. 1990; 27: 406-413.
Lee, J.S., Asano, E., Muzik, O. et al: Sturge-Weber syndrome: correlation between clinical course and FDG PET findings. Neurology. 2001; 57: 189-195.
De la Torre, A.J., Luat, A.F., Juhasz, C. et al: A Multidisciplinary Consensus for Clinical Care and Research Needs for Sturge-Weber Syndrome. Pediatr Neurol. 2018; 84: 11-20.
Alkonyi, B., Chugani, H.T. & Juhasz, C.: Transient focal cortical increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis. Epilepsia. 2011; 52: 1265-1272.
Kagawa, K., Chugani, D.C., Asano, E. et al: Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET). J Child Neurol. 2005; 20: 429-438.
Ferrendelli, J.A.: Lennox-Gastaut syndrome and positron emission tomography. Ann Neurol. 1987; 21: 3.
Ostendorf, A.P. & Ng, Y.T.: Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat. 2017; 13: 1131-1140.
Archer, J.S., Warren, A.E., Stagnitti, M.R., Masterton, R.A., Abbott, D.F. & Jackson, G.D.: Lennox-Gastaut syndrome and phenotype: secondary network epilepsies. Epilepsia. 2014; 55: 1245-1254.
Bordonne, M., Chawki, M.B., Doyen, M. et al: Brain (18)F-FDG PET for the diagnosis of autoimmune encephalitis: a systematic review and a meta-analysis. Eur J Nucl Med Mol Imaging. 2021; 48: 3847-3858.
Sayfalar
527-538
Gelecek
21 Eylül 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap DOI Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Lay Ergün E, Volkan Salancı B. Epilepsi Cerrahisine Hazırlıkta İlk Aşama ve Non-İnvazif Tetkiklerle Değerlendirme-Nükleer Tıp. Içinde: Canpolat M, editör. Canpolat, Temel Pediatrik Epilepsi [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 527-38. Erişim adresi: https://mail.omp35.books.akademisyen.net/index.php/akya/catalog/book/3122/chapter/12237
