Derin İnfiltratif Endometriosis Cerrahisinde Ağrı Skorlarını ve Hayat Kalitesini Postoperatif Medikal Tedavi İyileştirir Mi?
Özet
Endometriozis, endometrial bezlerin ve stromanın uterus boşluğunun dışında bulunması ve büyümesiyle karakterize kronik bir hastalıktır. Endometriotik implantların peritonun 5 mm'den daha altında olduğu derin infiltratif endometriozis, gastrointestinal sistemi, cul de sac ve üriner sistem etkileyerek reaktif inflamasyona, şiddetli fibroza ve yapışıklıklara yol açabilen hastalığın en şiddetli halidir. DİE tedavisinde cerrahi ile birlikte pek çok medikal ajan kullanılabilmektedir(1).
Endometriosis is a chronic swelling of the endometrial glands and stroma that grow outside the uterine cells. Deep infiltrative endometriosis, where endometriotic implants are less than 5 mm below the peritoneum, is the neurological most severe form that can affect the gastrointestinal tract, cul de sac and urinary tract, leading to reagent administration, severe fibrosis and adhesions. Many medical agents can be used together with surgery in the treatment of DIE (1).
Referanslar
Veronica B,Francesca G,Deborah A, et al.The natural evolution of untreated deep endometriosis and the effect of hormonal suppression: A systematic literature review and meta-analysis.Acta Obstetricia et Gynecologica Scandinavica;2024;103(9):1683-1903.https://doi.org/10.1111/aogs.14887
Audrey P, Vanessa P, Nicolas P, et al.Enhanced recovery after posterior deep infiltrating endometriosis surgery: a national study.Fertil Steril 2022 Feb;117(2):376-383. doi: 10.1016/j.fertnstert.2021.10.014.
Han Z, Yanbin W, Effects of various controlled ovarian hyperstimulation protocols and surgery on pregnancy outcomes in women with endometriosis Gynecol Endocrinology; 2024 Dec;40(1):2381504. Doi: 10.1080/09513590.2024.2381504.
Dousset B, Leconte M, Borghese B, et al.Complete surgery for low rectal endometriosis: long-term results of a 100-case prospective study. Ann Surg. 2010; 251: 887-895 DOI:10.1097/SLA.0b013e3181d9722d
Chapron C, Chiodo I, Leconte M, et al. Severe ureteral endometriosis: the intrinsic type is not so rare after complete surgical exeresis of deep endometriotic lesions.Fertil Steril. 2010; 93: 2115-2120 DOI:10.1016/j.fertnstert.2009.01.102
Ludovico M, Chiara Di T,,Giulia G, et al.The Efficacy of Dienogest in Reducing Disease and Pain Recurrence After Endometriosis Surgery: a Systematic Review and Meta-Analysis. Reprod Sci.2023 Nov; 30(11): 3135–3143.doi:10.1007/s43032-023-01266-0
Zheng YM, Peng C, Lu Y, et al. Incidence of deeply infiltrating endometriosis among 240 cases of pelvic endometriosis and analysis of its clinical and pathological characteristics. Zhonghua Fu Chan Ke Za Zhi. 2020;55(6):384–389. DOI:10.3760/cma.j.cn112141-20191202-00654
Edgardo R. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000Res. 2019; 8: F1000 Faculty Rev-529.doi:10.12688/f1000research.14817.1
Murat A.Surgery for endometriosis-related pain. Womens Health (Lond).2015 Aug;11(5):665-9.doi: 10.2217/whe.15.52.
Qihui G, Renata Voltolini V,Jalid S, et al.Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?Int.J.Mol.Sci.2023,24(2),1633;https://doi.org/10.3390/ijms24021633
Sarah J Holdsworth-C, Jessica C, Dorothy A M, et al.Predicting disease recurrence in patients with endometriosis: an observational study.BMC Med. 2024 Aug 7;22(1):320. doi: 10.1186/s12916-024-03508-7.
Christina R, Athanasios M, Eirini C, Dimitris Malligiannis N, et al.Gonadotropin-Releasing Hormone (GnRH)/GnRH Receptors and Their Role in the Treatment of Endometriosis.Cureus. 2023 Apr 26;15(4):e38136.doi: 10.7759/cureus.38136
Francesco L,Silvia V, Federico T, et al.Long-term treatment for endometriosis with dienogest: efficacy, side effects and tolerability Gynecol Endocrinol.2024 Dec;40(1):2336121. doi:10.1080/09513590.2024.2336121. Epub 2024 Apr 5.
Yutaka O, Yoshifumi S, Masataka T, et al.Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis-associated pain: phase 2 safety and efficacy 24-week results. BMC Womens Health..2021 Jun 21;21(1):250.doi: 10.1186/s12905-021-01393-3
Sawsan As-S, Mauricio S A, Galyna R, et al.Impact of relugolix combination therapy on functioning and quality of life in women with endometriosis-associated pain.Fertil Steril.2024 Jun 19:S0015-0282(24)00540-5.doi: 10.1016/j.fertnstert.2024.06.009.
Eric S Surrey.GnRH agonists in the treatment of symptomatic endometriosis: a review.F S Reports.2022 Nov 21;4(2 Suppl):40-45.doi: 10.1016/j.xfre.2022.11.009
Veronica B, Francesca G, Deborah A, et al.The natural evolution of untreated deep endometriosis and the effect of hormonal suppression: A systematic literature review and meta-analysis.Acta Obstet Gynecol Scand.2024 Sep;103(9):1722-1735. doi: 10.1111/aogs.14887.
Audrey P, Vanessa P, Nicolas P, et al.Enhanced recovery after posterior deep infiltrating endometriosis surgery: a national study.Fertil Steril 2022 Feb;117(2):376-383. doi: 10.1016/j.fertnstert.2021.10.014.
Han Z, Yanbin W, Effects of various controlled ovarian hyperstimulation protocols and surgery on pregnancy outcomes in women with endometriosis Gynecol Endocrinology; 2024 Dec;40(1):2381504. Doi: 10.1080/09513590.2024.2381504.
Dousset B, Leconte M, Borghese B, et al.Complete surgery for low rectal endometriosis: long-term results of a 100-case prospective study. Ann Surg. 2010; 251: 887-895 DOI:10.1097/SLA.0b013e3181d9722d
Chapron C, Chiodo I, Leconte M, et al. Severe ureteral endometriosis: the intrinsic type is not so rare after complete surgical exeresis of deep endometriotic lesions.Fertil Steril. 2010; 93: 2115-2120 DOI:10.1016/j.fertnstert.2009.01.102
Ludovico M, Chiara Di T,,Giulia G, et al.The Efficacy of Dienogest in Reducing Disease and Pain Recurrence After Endometriosis Surgery: a Systematic Review and Meta-Analysis. Reprod Sci.2023 Nov; 30(11): 3135–3143.doi:10.1007/s43032-023-01266-0
Zheng YM, Peng C, Lu Y, et al. Incidence of deeply infiltrating endometriosis among 240 cases of pelvic endometriosis and analysis of its clinical and pathological characteristics. Zhonghua Fu Chan Ke Za Zhi. 2020;55(6):384–389. DOI:10.3760/cma.j.cn112141-20191202-00654
Edgardo R. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000Res. 2019; 8: F1000 Faculty Rev-529.doi:10.12688/f1000research.14817.1
Murat A.Surgery for endometriosis-related pain. Womens Health (Lond).2015 Aug;11(5):665-9.doi: 10.2217/whe.15.52.
Qihui G, Renata Voltolini V,Jalid S, et al.Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?Int.J.Mol.Sci.2023,24(2),1633;https://doi.org/10.3390/ijms24021633
Sarah J Holdsworth-C, Jessica C, Dorothy A M, et al.Predicting disease recurrence in patients with endometriosis: an observational study.BMC Med. 2024 Aug 7;22(1):320. doi: 10.1186/s12916-024-03508-7.
Christina R, Athanasios M, Eirini C, Dimitris Malligiannis N, et al.Gonadotropin-Releasing Hormone (GnRH)/GnRH Receptors and Their Role in the Treatment of Endometriosis.Cureus. 2023 Apr 26;15(4):e38136.doi: 10.7759/cureus.38136
Francesco L,Silvia V, Federico T, et al.Long-term treatment for endometriosis with dienogest: efficacy, side effects and tolerability Gynecol Endocrinol.2024 Dec;40(1):2336121. doi:10.1080/09513590.2024.2336121. Epub 2024 Apr 5.
Yutaka O, Yoshifumi S, Masataka T, et al.Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis-associated pain: phase 2 safety and efficacy 24-week results. BMC Womens Health..2021 Jun 21;21(1):250.doi: 10.1186/s12905-021-01393-3
Sawsan As-S, Mauricio S A, Galyna R, et al.Impact of relugolix combination therapy on functioning and quality of life in women with endometriosis-associated pain.Fertil Steril.2024 Jun 19:S0015-0282(24)00540-5.doi: 10.1016/j.fertnstert.2024.06.009.
Eric S Surrey.GnRH agonists in the treatment of symptomatic endometriosis: a review.F S Reports.2022 Nov 21;4(2 Suppl):40-45.doi: 10.1016/j.xfre.2022.11.009
Veronica B, Francesca G, Deborah A, et al.The natural evolution of untreated deep endometriosis and the effect of hormonal suppression: A systematic literature review and meta-analysis.Acta Obstet Gynecol Scand.2024 Sep;103(9):1722-1735. doi: 10.1111/aogs.14887.
Sayfalar
293-296
Gelecek
21 Ocak 2025
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